Today, human pluripotent stem cell technologies find widespread application across biomedical research, as models for early human development, as platforms for functional human genomics, as tools for the study of disease, drug screening and toxicology, and as a renewable source of cellular therapeutics for a range of intractable diseases. The foundations of this human pluripotent stem cell revolution rest on advances in a wide range of disciplines, including cancer biology, assisted reproduction, cell culture and organoid technology, somatic cell nuclear transfer, (...) primate embryology, single‐cell biology, and gene editing. This review surveys the slow emergence of the study of human pluripotency and the exponential growth of the field during the past several decades. (shrink)

Emotion evaluations are assumed to play a crucial role in the emotion regulation process. We tested a postulate from our framework of emotion dysregulation (Nowak, U., Wittkamp, M. F., Clamor, A., & Lincoln, T. M. [2021]. Using the Ball-in-Bowl metaphor to outline an integrative framework for understanding dysregulated emotion. Frontiers in Psychiatry, 12, 118), namely that the extent to which individuals evaluate an emotion as harmful and their personal resources to modify and accept/tolerate the emotion as sufficient predict the subsequent (...) use of regulation strategies. Participants (n = 118) from a community sample took part in an experience-sampling assessment over 7 days including 10 daily paired measurements. The first measured momentary affective valence and arousal along with harmfulness evaluations and evaluations of personal resources to modify and accept/tolerate an emotion. The second followed three minutes later and measured emotion regulation strategies. The more harmful individuals evaluated an emotion, the more likely they were to use an emotion regulation strategy. The more harmful individuals evaluated an emotion, and the less sufficient they evaluated their personal resources to accept/tolerate an emotion, the more likely they were to use a maladaptive emotion regulation strategy. We conclude that emotions that people evaluate as harmful or difficult to accept are most likely to be regulated in a maladaptive manner. This implies that modifying beliefs about emotions could represent a promising treatment approach. (shrink)

The core thesis of the paper is that the constitution of biological science begins with a conceptual innovation with far-reaching consequences with effect up to the present: by conceiving the parts of living beings as organs (that is, as tools), Aristotle laid the foundation stone for a functional explanation of animate nature. Comparative anatomy is thus transformed from a merely descriptive to an explanatory theory. The point of the discussion is above all that a functional explanation must not be confused (...) with the sort of teleology according to which the function of an organ is understood as the cause of its existence. The first section outlines the theoretical motives that Aristotle adduces in arguing for biology (against contemporary contempt for biological research). The second step addresses the significance of the parts of animals in Aristotle's larger collection of zoological material, the Historia animalium . The third section demonstrates how in the major explanatory work De partibus animalium the term organon takes on the status of a key methodological concept. Finally, the fourth section discusses the significance of the Aristotelian determination of the organic with respect to current discourses in natural science. (shrink)

By fostering bonding, music illustrates marvelously its ability to induce emotional experience. But, music can induce emotion more generally as well. To help explain how music fosters bonding and induces other emotions, I propose that music derives this power from the evolution of what I term “gestural messaging.”.

Much was accomplished in the last decade in understanding how the adaptive immune system evolved to combat pathogens. Essential features of antigen presentation and T lymphocyte recognition were decipherd, setting the stage for further studies that elucidated basic elements of lymphocyte differentiation (including positive and negative selection during lymphocyte ontogeny) and the major interactions that occur among cells in secondary lymphoid organs in an ongoing immune response. The major challenges of today are found in the burgeoning fields of programmed cells (...) death, enzymology of recombination and somatic mutation, development of memory, and the recognition of pathogens by unconventional lymphocytes. (shrink)

In fr. 69 Smith, the Epicurean Diogenes of Oinoanda, like Lucretius 4.353–63, explains why a square tower viewed from the distance appears to be round. The explanation is that εἲδωλα, filmy atomic images, emanating from the tower, are forced out of shape by the air through which they pass on their way to our eyes. Diogenes’ account is fragmentarily preserved on a stone which I discovered in 1970. The stone bears the right half of one fourteen-line column and the left (...) half of a second one. I first published the text in 1971. When, twenty years later, I came to deal with it again, in preparing an edition of all the known fragments, I was able, thanks in no small measure to the discussions and suggestions of other scholars, whose names can be seen in my apparatus criticus, to print a text which represents a considerable advance on that of the editio princeps. However, with so much of what Diogenes wrote missing, there has remained scope for further progress, and in this note I correct an error—an error present not only in my text, but also on the stone itself. (shrink)

In 294 most modern scholars either accept rapidique or adopt Lachmann's rapideque. An exception is Romanes, who oddly favours rapidisque, which he takes with impetibus crebris, placing a comma after corripiunt. If rapidique is read, one has to assume that Lucretius is writing as though venti, not flamina, were the subject. There are parallels for this kind of grammatical irregularity , but there is no need to assume an irregularity here, for, as E. J. Kenney has pointed out to me, (...) the right reading is almost certainly rapidoque. rapidoque was favoured by Lambinus, but did not originate with him. He notes ‘ex libris scriptis alii habent, rapidoque rotanti, alii rapidique rotanti’, and Pius knew rapidoque, which is printed in the ed. Juntina . rapido…turbine is strongly supported by 1.273 rapido…turbine and 6.668 rapidus…turbo, also by subito…turbine in 1.279, a line which, as we shall see, is to be closely compared with 1.294. (shrink)

El artículo enfoca los problemas de convivencia en las ciudades latinoamericanas, marcadas por procesos de urbanización sin articulación, regidos por lógicas de poder y caracterizados por la falta de equilibrio y equidad. Se exploran las posibilidades de pasar de territorios de supervivencia, con relaciones sociales de dominio y violencia, a espacios de comunicación y a lugares de sentido, a través de prácticas, políticas y estrategias de convivencia. The article focuses on the problems of living in Latin American cities, marked by (...) urbanization processes without articulation, governed by logics of power and characterized by a lack of balance and fairness. It explores the possibilities to move from territories of survival, with social relationships of domination and violence, to communicative spaces and places of meaning through practices, policies and strategies of coexistence. (shrink)

En su artículo “On Knowing One’s Own Mind” (1988), Shoemaker argumenta en favor de tres afirmaciones: (1) se requiere un autoconocimiento directo (self-acquaintance) para la cooperación racional con otras personas (porque ésta depende de que podamos decirles qué es lo que creemos e intentamos hacer); (2) el autoconocimiento directo es necesario para la deliberación sobre qué creer y qué hacer (porque no podemos ajustar racionalmente creencias y deseos sin saber qué creencias y deseos tenemos); y (3) el autoconocimiento directo es (...) una consecuencia inmediata de nuestra capacidad para reconocer el carácter paradójico de oraciones que ejemplifican la paradoja de Moore. En este capítulo trato de mostrar que las afirmaciones (1) y (2) no son correctas; la cooperación se puede llevar acabo comunicándonos exclusivamente sobre (supuestos) hechos y acciones y el ajuste racional de creencias normalmente sucede de una manera automática a un nivel de primer orden. Sin embargo, la afirmación (3) indica una relación interesante entre nuestras capacidades conceptuales y lingüísticas, por un lado, y, por el otro, nuestra capacidad de “contestar la pregunta de si creo que p poniendo en marcha el proceso (cualquiera que éste sea) mediante el cual respondo a la pregunta de si p” (Evans, 1982: 225). (shrink)

Biology is the most extensive field in the Corpus Aristotelicum. In his fundamental work De anima, Aristotle tries to fix the borders of this life science. The term ψυχή has a twofold explanatory status. On the one hand, ψυχή is understood as a principle of all living beings. On the other hand, it is understood as a cause of the fact that all living beings are alive. The paper is divided into three sections. The first part shows why Aristotle discusses (...) these issues in a work entitled Περὶ ψυχῆς. Since Pythagoras and Heraclitus, ψυχή was understood as a life principle: Pythagoras believed that men, animals and plants share the same nature: they are all ἔμψυχα and they are homogenous qua ψυχή. The second part of this article deals with Aristotle’s definition of the soul in DA II: ψυχή is the principle of all living things. This establishes the external criteria to divide living and non-living beings and the internal criteria to divide living beings. The third part of this paper is concerned with the methodological consequences of this definition: the life functions are the central explanandum in Aristotle’s biology. De anima II defines such various life-functions as nourishment, sense-perception and locomotion. These capacities contour the main fields of the philosopher’s biological investigation. For Aristotle, the faculty of reproduction is a subtype of nourishment. Reproduction is the most important and most natural function of all living beings. Genetics is, therefore, the most important field in Aristotle’s biology. (shrink)

The ninth and last poem in Book 4 of the Silvae is an amusing hendecasyllabic piece in which Statius, addressing Plotius Grypus, reproves him for having sent him for the Saturnalia a tatty, second-hand copy of a boring book in return for the fine, expensive, new volume which was Statius' present to him. The poem includes a long list of humble and/or poor-quality items, any of which, it is suggested, would have been more acceptable than Grypus' gift. Included in the (...) list are eggs. (shrink)

El artículo enfoca los problemas de convivencia en las ciudades latinoamericanas, marcadas por procesos de urbanización sin articulación, regidos por lógicas de poder y caracterizados por la falta de equilibrio y equidad. Se exploran las posibilidades de pasar de territorios de supervivencia, con relaciones sociales de dominio y violencia, a espacios de comunicación y a lugares de sentido, a través de prácticas, políticas y estrategias de convivencia.The article focuses on the problems of living in Latin American cities, marked by urbanization (...) processes without articulation, governed by logics of power and characterized by a lack of balance and fairness. It explores the possibilities to move from territories of survival, with social relationships of domination and violence, to communicative spaces and places of meaning through practices, policies and strategies of coexistence. (shrink)

The abbey of Conques and its dominant church dedicated to St Foy are today one of the most prominent examples of the harmonic relationship between medieval sacred architecture and nature. This article considers the medieval landscape of Conques from an environmental-historical perspective by analyzing early medieval writings about the abbey. It focuses on early descriptions, which often contain literary, hagiographical topoi depicting ideal, symbolic, or imagined landscapes - sometimes, however, also partially reflecting reality. These descriptions serve, with caution, to investigate (...) the local environment, its transformation, and its effect on the early history of the monastery. In addition, the article delves into the eleventh-century Liber miraculorum sanctae Fidis to investigate strategies that the monastic community used to control St Foy’s estates not only close to the abbey but also in the wider region. Analysis reveals the environment conditions, their impact on the history, and ways in which the monastic community sacralized the landscape through real processions and miracle stories to control it. (shrink)

William James catalogued an amazing diversity of religious experiences. Yet even the pluralistic James was able to find a nucleus, consisting of an uneasiness and its solution, ‘1. The uneasiness, reduced to its simplest terms, is a sense that there is something wrong about us as we naturally stand. 2. The solution is a sense that we are saved from the wrongness by making proper connection with the higher powers.’ But by stressing the moral factor, James seems to exclude those (...) who stress rather the sense of mystery stemming from man's theoretical limitations. Einstein, for example, writes: ‘The most beautiful thing we can experience is the mysterious side of life. It is the deep feeling which is at the cradle of all true art and science. In this sense, and only in this sense, I count myself amongst the most deeply religious people.’ For Einstein as for Pascal : ‘The last proceeding of reason is to recognise that there is an infinity of things which are beyond it.’ Thus I propose the following revision of James' conception of the nucleus of the religious experience: uneasy awareness of the limitations of man's moral or theoretical powers, especially when reality is restricted to sense data and natural objects; awe-full awareness of a further reality—beyond or behind or within; conviction that participation with this further reality is of supreme importance. (shrink)

“Every surgeon carries within himself a small cemetery where from time to time he goes to pray—a place of bitterness and regret, where he must look for an explanation of his failures” René Leriche,...

In no field of knowledge did Aristotle leave more writings than in biol­ogy. He conducted research for longer and more intensively in zoology than in any other field. In these writings he mentions a good 550 animal and 60 plant species. While this includes the internal anatomy of around 110 animals, he dissected 60 species himself. The present contribution deals with the epistemic motifs and the meaning of Aristotelian biology in the context of his scientific curriculum. It is thus demonstrated (...) that in De anima Aristotle’s actual explanations are preceded by an investi­gation of the principles, which aims to differentiate living objects from inanimate ones, and to develop a method of explanation based on the species-specific vital functions of living beings. This article provides an overview of the four main disciplines of Aristotelian biology: compara­tive anatomy, physiology, genetics and behavioral research. The text offers tabular overviews of the animals and plants dealt with by Aristotle. (shrink)

What made Socrates so special that he became the object of mockery, slander and hate? The answer in the Apology is expressed in the formula of the ‘Socratic pragma’. Plato claims that Socrates’ philosophical enterprise was a reaction to the Delphic oracle according to which no living Greek was wiser than Socrates. But does this really explain what it pretends to explain? The paper argues that this explanation tells us more about Plato’s philosophical approach than about this alleged turning point (...) in Socrates’ life. Our understanding of Socrates’ philosophical development should be based on other Platonic dialogues and the Old Comedy as well, for they inform us about the historical shift of philosophical interest from questions of physics to questions of ethics and political anthropology. (shrink)